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rac2 proto-oncogene protein; EN7 protein; Ras-related C3 botulinum toxin substrate 2; p21-Rac2; small G protein; GX (RAC2)
Function:
- plasma membrane-associated small GTPase
- cycles between an active GTP-bound & inactive GDP-bound state
- role in the regulation of neutrophil NADPH oxidase
- interacts with DOCK2, which may activate it
Structure: belongs to the small GTPase superfamily, Rho family
Compartment:
- cytoplasm, membrane-associated when activated
Expression: hematopoietic specific
Pathology:
- defects in RAC2 are the cause of neutrophil immunodeficiency syndrome [MIM:608203]
Interactions
molecular events
General
rac proto-oncogene protein (p21rac)
Properties
SIZE: entity length = 192 aa
MW = 21 kD
COMPARTMENT: cytoplasm
plasma membrane
CELL: neutrophil
MOTIF: GTP-binding site
SITE: 10-17
Effector region {32-40}
GTP-binding site
SITE: 57-61
GTP-binding site
SITE: 115-118
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: geranylgeranyl{C20}
BOUND-VIA: cysteine residue
Database Correlations
OMIM correlations
MORBIDMAP 602049
UniProt P15153
Pfam PF00071
Entrez Gene 5880
Kegg hsa:5880
References
- UniProt :accession P15153
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/RAC2ID42021ch22q13.html
- RAC2base; Note: RAC2 mutation db
http://bioinf.uta.fi/RAC2base/
- Kahn RA, Der CJ, Bokoch GM.
The ras superfamily of GTP-binding proteins: guidelines on
nomenclature.
FASEB J. 1992 May;6(8):2512-3.
PMID: 1592203
- Segal AW, Abo A.
The biochemical basis of the NADPH oxidase of phagocytes.
Trends Biochem Sci. 1993 Feb;18(2):43-7. Review.
PMID: 8488557
- Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L.
A brain serine/threonine protein kinase activated by Cdc42
and Rac1.
Nature. 1994 Jan 6;367(6458):40-6.
PMID: 8107774
Component-of
molecular complex