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transcription initiation factor TFIID subunit 12; transcription initiation factor TFIID 20/15 kD subunits; TAFII-20/TAFII-15; TAFII20/TAFII15 (TAF12, TAF15, TAF2J, TAFII20)
Function:
- components of TFIID complex, PCAF histone acetylase complex, STAGA transcription coactivator-HAT complex & TBP-free TAFII complex (TFTC)
- interacts directly with TBP
- additional interactions between TAFII20 & TAFII28 or TAFII30
Structure:
- belongs to the TAF12 family
- contains 1 histone-fold domain
Compartment: nucleus
Alternative initiation: named isoforms=2
Expression: ubiquitous
General
phosphoprotein
transcription factor IID subunit
Properties
SIZE: entity length = 161 aa
MW = 18 kD
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T43}
Ser phosphorylation site {S51}
Thr phosphorylation site {T59}
Database Correlations
OMIM 600773
UniProt Q16514
Pfam PF03847
Entrez Gene 6883
Kegg hsa:6883
References
- Chiang CM, Roeder RG.
Cloning of an intrinsic human TFIID subunit that interacts
with multiple transcriptional activators.
Science. 1995 Jan 27;267(5197):531-6.
PMID: 7824954
- UniProt :accession Q16514
- NIEHS-SNPs
http://egp.gs.washington.edu/data/taf12/
Component-of
PCAF complex; coactivator for p53/TP53-dependent transcriptional activation; PCAF histone acetylase complex