cyclin-dependent kinase 4 inhibitor C selections

cyclin-dependent kinase 4 inhibitor C; p18-INK4c; cyclin-dependent kinase 6 inhibitor; p18-INK6 (CDKN2C, CDKN6)

Function: - interacts strongly with CDK6, weakly with CDK4 - inhibits cell growth & proliferation with a correlated dependence on endogenous retinoblastoma protein RB - heterodimer of p18ink6 with CDK6 Structure: - belongs to the CDKN2 cyclin-dependent kinase inhibitor family - contains 4 ANK repeats Expression: - highest levels found in skeletal muscle - also found in pancreas & heart Pathology: defects in CDKN2C are involved in tumor formation

Interactions

molecular events

General

ankyrin repeat domain protein (ANKRD) cyclin-dependent kinase inhibitor (CDKI, CDKN) nuclear protein

Properties

SIZE: entity length = 168 aa MW = 18 kD COMPARTMENT: cell nucleus MOTIF: ankyrin repeat NAME: ankyrin repeat SITE: 4-33 ankyrin repeat NAME: ankyrin repeat SITE: 37-65 ankyrin repeat NAME: ankyrin repeat SITE: 69-98 ankyrin repeat NAME: ankyrin repeat SITE: 102-132 INHIBITS: protein kinase

Database Correlations

OMIM 603369 UniProt P42773 Pfam PF00023 Entrez Gene 1031 Kegg hsa:1031

References

UniProt :accession P42773
NIEHS-SNPs http://egp.gs.washington.edu/data/cdkn2c/

Component-of

molecular complex

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