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FK506-binding protein 2 (13 kD FK506-binding protein, FKBP2)
Function:
- associates with ryanodine receptor (RYR-2) in cardiac muscle sarcoplasmic reticulum
- may play a physiological role in excitation-contraction coupling in cardiac muscle
- there are four molecules of FKBP12.6 per heart muscle RYR
- PPIases accelerate the folding of proteins
- catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides inhibited by both FK506 & rapamycin
peptidylproline (omega=180) peptidylproline (omega=0)
Structure:
- belongs to the FKBP-type PPIase family, FKBP1 subfamily
- contains 1 PPIase FKBP-type domain
Compartment: cytoplasm (putative)
Alternative splicing: named isoforms=2
Expression:
- ubiquitous for both isoform
- highest levels in brain & thymus
Pathology:
- may contribute to the immunosuppressive & toxic effects of FK506 & rapamycin.
General
FK506 binding protein (FKBP)
Properties
SIZE: MW = 13 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: active site
binding site
FOR-BINDING-OF: sirolimus
Database Correlations
OMIM 186946
UniProt P26885
ENZYME 5.2.1.8
References
- Martinus RD et al
Role of chaperones in the biogenesis and maintenance of the
mitochondrion.
FASEB J. 1995 Mar;9(5):371-8. Review.
PMID: 7896006