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p130Cas-associated protein; p140Cap; SNAP-25-interacting protein; SNIP; P140 (SRCIN1, KIAA1684)
Function:
- delays the onset of cell spreading in the early stages of cell adhesion to fibronectin
- role in Ca+2-dependent exocytosis from PC12 cells
- interacts with the N-terminal coiled-coil region of SNAP25 (putative)
- interacts with BCAR1/p130Cas through its C-terminal domain
- Tyr-phosphorylated in response to EGF & to cell adhesion to integrin ligands
Structure: belongs to the p140Cap family
Compartment:
- cytoplasm, cytoskeleton
- localized to the perinuclear region, lamellopodia, cortical actin & actin stress fibers but not to focal adhesions
Alternative splicing: named isoforms=3
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: MW = 112 kD
entity length = 1055 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S97}
Ser phosphorylation site {S179}
Ser phosphorylation site {S215}
Ser phosphorylation site {S234}
Ser phosphorylation site {S385}
Ser phosphorylation site {S394}
coiled coil {436-460}
Ser phosphorylation site {S476}
Thr phosphorylation site {T509}
SNAP25 interaction {519-569}
coiled coil {523-650}
Ser phosphorylation site {S738}
Ser phosphorylation site {S779}
coiled coil {799-816}
Ser phosphorylation site {S859}
Ser phosphorylation site {S915}
Database Correlations
UniProt Q9C0H9
References
UniProt :accession Q9C0H9