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oxysterol-binding protein-related protein 1; ORP-1; OSBP-related protein 1 (OSBPL1A, ORP1, OSBP8, OSBPL1, OSBPL1B)

Function: - binds phospholipids - strong binding to phosphatidic acid - weak binding to phosphatidylinositol 3-phosphate (putative) - interacts with VAPA (putative) Structure: - belongs to the OSBP family - contains 3 ANK repeats - contains 1 PH domain Alternative splicing: named isoforms=3

Related

oxysterol; hydroxysterol

General

ankyrin repeat domain protein (ANKRD) oxysterol-binding like protein (OSBPL) phosphoprotein

Properties

SIZE: entity length = 950 aa MW = 108 kD COMPARTMENT: cellular membrane MOTIF: ankyrin repeat NAME: ankyrin repeat SITE: 47-76 ankyrin repeat NAME: ankyrin repeat SITE: 80-109 ankyrin repeat NAME: ankyrin repeat SITE: 175-204 PH domain {235-334} coiled coil {430-463} Ser phosphorylation site {S499} coiled coil {877-913}

Database Correlations

OMIM 606730 UniProt Q9BXW6 PFAM correlations Entrez Gene 114876 Kegg hsa:114876

References

  1. UniProt :accession Q9BXW6
  2. OMIM :accession 606730