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oxymetazoline (Afrin)
Tradename: Afrin.
Indications:
- acute relief of nasal congestion & nasopharyngeal mucosal congestion
Dosage: 2 drops/sprays per nostril BID. 0.025% & 0.05%.
Adverse effects:
- common (> 10%)
- nasal burning
- rebound congestion (after 3-10 days): rhinitis medicamentosa
- sneezing
- less common (1-10%)
- stinging, dryness
- see phenylephrine
Mechanism of action: alpha-2 adrenergic receptor agonist
Interactions
drug adverse effects (more general classes)
Related
phenylephrine (Neo-Synephrine, Mydrifin, sudafed PE, PE)
General
alpha-2 adrenergic receptor agonist
decongestant
Properties
AGONIST-FOR: alpha-2 adrenergic receptor
MISC-INFO: elimination route LIVER
pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Faga LJ, American Family Physician 58:1795-1802, 1998
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998