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oxtriphylline [choline theophyllinate] (Choledyl)
Tradename: Choledyl. (61% anhydrous theophylline).
Indications:
- reversible bronchospasm
- symptomatic treatment of asthma
- chronic bronchitis
Contraindications:
- uncontrolled arrhythmias
Caution:
1) peptic ulcer disease
2) hyperthyroidism
3) congestive heart failure
4) COPD
5) liver disease
pregnancy-category C
safety in lactation ?
Dosage:
1) adults: 4.7 mg/kg PO TID; administer sustained release every 12 hours
2) children:
a) 1-9 years: 6.2 mg/kg every 6 hours
b) 9-16 years: 4.7 mg/kg every 6 hours
Tabs: 100 & 200 mg.
Sustained release: 400 mg, 600 mg.
Elixir: 50 & 100 mg/5 mL.
Sustained action: Choledyl SA:
- 400-600 mg PO BID
Tabs: 400 & 600 mg.
Pharmacokinetics: elimination: liver
Adverse effects:
1) not common (1-10%)
- tachycardia, nervousness, restlessness, nausea/vomiting
2) uncommon (< 1%)
- insomnia, irritablity, seizures, rash, gastric irritation, tremor, allergic reaction
Drug interactions:
1) smoking alters metabolism
2) cimetidine & possibly ranitidine
3) rifampin
4) phenytoin
5) barbiturates
6) ciprofloxacin
7) erythromycin
Mechanism of action:
- bronchodilator
Interactions
drug interactions
Related
asthma
General
methylxanthine
antiasthmatic agent
pharmacologic combination
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 8th ed.
Gilman et al, eds. Permagon Press/McGraw Hill pg 628
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Deprecated Reference
Components
choline
theophylline (Slo-Phyllin, Elixophyllin, Uniphyl, Theo-24, Theo-Dur, Slo-bid, Theolair)