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oxoeicosanoid receptor 1 (G-protein coupled receptor TG1019, 5-oxo-ETE G-protein coupled receptor, G-protein coupled receptor 170, G-protein coupled receptor R527, OXER1, GPR170, TG1019)
Function:
1) receptor for eicosanoids & polyunsaturated fatty acids
a) 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE),
b) 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE)
c) arachidonic acid
2) coupled to the Gi/Go heteromeric G proteins
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: membrane
Expression:
- greatest in liver, kidney, peripheral leukocyte, lung, spleen
- not expressed in brain
Related
5-hydroperoxy-eicosatetraenoate
arachidonate; arachidonic acid [C20:4w6, ARA]
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 46 kD
entity length = 423 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-97}
MOTIF: N-glycosylation site {N44}
serine-rich region {46-92}
MOTIF: serine residue (SEVERAL)
transmembrane domain {98-118}
cytoplasmic loop {119-126}
transmembrane domain {127-147}
exoplasmic loop {148-168}
MOTIF: cysteine residue {C165}
MODIFICATION: cysteine residue {C237}
transmembrane domain {169-191}
cytoplasmic loop {192-211}
transmembrane domain {212-232}
exoplasmic loop {233-254}
MOTIF: cysteine residue {C237}
MODIFICATION: cysteine residue {C165}
transmembrane domain {255-275}
cytoplasmic loop {276-295}
transmembrane domain {296-316}
exoplasmic loop {317-336}
transmembrane domain {337-357}
cytoplasmic domain {358-423}
Database Correlations
UniProt Q8TDS5
Pfam PF00001
Kegg hsa:1651
References
UniProt :accession Q8TDS5