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Interactions
molecular events
Specific
2,4-dienoyl-CoA reductase, mitochondrial (2,4-dienoyl-CoA reductase [NADPH], 4-enoyl-CoA reductase [NADPH], DECR1, DECR)
3-beta-HSD family protein ENSP00000330812 (SDR42E2)
3-ketodihydrosphingosine reductase; KDS reductase; 3-dehydrosphinganine reductase; follicular variant translocation protein 1; FVT-1 (KDSR FVT1)
5,10-methylenetetrahydrofolate reductase (MTHFR)
5,6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase; tyrosinase-related protein 1; TYRP1, catalase B; glycoprotein-75; gp75; brown [b] locus protein homolog; CAS2 protein; melanoma antigen gp75; monophenol monooxygenase homolog (TYRP1, CAS2, TYRP, TYRRP)
7-dehydrocholesterol delta-7 reductase
7-dehydrocholesterol reductase; 7-DHC reductase; sterol reductase SR-2; sterol delta(7)-reductase (DHCR7 D7SR)
acyl-coenzyme A oxidase (ACOX)
acyl-coenzyme A oxidase-like protein (acyl-CoA oxidase-like protein, ACOXL)
adrenodoxin reductase (ferredoxin NADP reductase, FDXR)
alcohol oxidoreductase
aldehyde oxidoreductase
aldo-keto reductase family 1 member C-like protein 1 (AKR1CL1)
aldo-keto reductase family 1 member C-like protein 2; testis-specific protein HTSP; LoopADR (AKR1CL2, AKRDC1, AKR1E2)
all-trans-retinol 13,14-reductase; all-trans-13,14-dihydroretinol saturase; RetSat; PPAR-alpha-regulated & starvation-induced gene protein (RETSAT, PPSIG, UNQ439/PRO872)
amine oxidoreductase
apoptosis-inducing factor 1, mitochondrial; programmed cell death protein 8 (AIFM1, AIF, PDCD8)
apoptosis-inducing factor-like protein (AIFL, AIFM3)
benzamidoxime prodrug-converting complex
biliverdin reductase
C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase; includes: methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase; formyltetrahydrofolate synthetase (MTHFD1, MTHFC, MTHFD)
C-4 methylsterol oxidase; methylsterol monooxygenase (SC4MOL, DESP4, ERG25, MSMO1)
carbonyl reductase 4 (CBR4)
ceruloplasmin; ferroxidase (CP)
cobalamin reductase
Coproporphyrinogen-III oxidase, mitochondrial; COX; Coprogen oxidase; Coproporphyrinogenase (CPOX, CPO, CPX)
cytochrome
cytochrome b ascorbate-dependent protein 3; cytochrome b561 family member A3; lysosomal cytochrome b; Lcytb (CYB561A3, CYBASC3, LCYTB, PSEC0259)
cytochrome b reductase 1 (duodenal cytochrome b, Ferric- chelate reductase 3) (CYBRD1 DCYTB FRRS3)
cytochrome oxidase
cytochrome reductase
D-aspartate oxidase (DASOX, DDO)
dehydrogenase
dehydrogenase/reductase SDR family member 4-like 1 (DHRS4L1)
delta(24)-sterol reductase; 24-dehydrocholesterol reductase; 3-beta-hydroxysterol delta-24-reductase; diminuto/dwarf1 homolog; seladin-1 (DHCR24. KIAA0018)
desmosterol reductase or desmosterol to cholesterol enzyme
diaphorase
dihydropteridine reductase (HDHPR, quinoid dihydropteridine reductase, QDPR, DHPR)
dual oxidase 1; large NOX 1; long NOX 1; NADPH thyroid oxidase 1; thyroid oxidase 1 (DUOX1, DUOX, LNOX1, THOX1)
dual oxidase 2; large NOX 2; long NOX 2; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; thyroid oxidase 2; p138 thyroid oxidase (DUOX2 LNOX2 THOX2)
Ecto-NOX disulfide-thiol exchanger 1; constitutive ecto-NOX; cNOX; candidate growth-related & time keeping constitutive hydroquinone [NADH] oxidase; cCNOX; cell proliferation-inducing gene 38 protein; [Includes: hydroquinone [NADH] oxidase; protein disulfide-thiol oxidoreductase] (ENOX1, PIG38)
electron transfer flavoprotein (ETF)
elongation of very long chain fatty acids protein 1 (ELOVL1, SSC1, CGI-88)
ERO1-like protein alpha; ERO1-L; ERO1-L-alpha; endoplasmic oxidoreductin-1-like protein; oxidoreductin-1-L-alpha (ERO1L)
ERO1-like protein beta; ERO1-L-beta; endoplasmic oxidoreductin-1-like protein B; oxidoreductin-1-L-beta (ERO1LB)
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1)
fatty acid synthase; includes: [acyl-carrier-protein] S-acetyltransferase; [acyl-carrier-protein] S-malonyltransferase; 3-oxoacyl-[acyl-carrier-protein] synthase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; enoyl-[acyl-carrier-protein] reductase; Oleoyl-[acyl-carrier-protein] hydrolase (FASN, FAS)
Fatty acyl-CoA reductase 1 (male sterility domain-containing protein 2, MLSTD2, FAR1, UNQ2423/PRO4981)
fatty acyl-CoA reductase 2 (male sterility domain- containing protein 1, MLSTD1, FAR2)
ferric-chelate reductase 1 (stromal cell-derived receptor 2, SDR-2, FRRS1, SDFR2, SDR2)
ferritin, mitochondrial
flavoprotein oxidoreductase MICAL3 (protein MICAL-3, MICAL3, KIAA1364)
gamma-interferon-inducible lysosomal thiol reductase; gamma-interferon-inducible protein IP-30 (IFI30 GILT)
GDP-L-fucose synthetase (protein FX, red cell NADPH-binding protein, GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase, tissue-specific transplantation antigen 3, TSTA3)
glucose-fructose oxidoreductase domain-containing protein 1 (GFOD1)
Glucose-fructose oxidoreductase domain-containing protein 2 (GFOD2)
glutaredoxin (GLRX)
glutaredoxin-2, mitochondrial (GLRX2, GRX2, CGI-133)
glutathione reductase (GSR)
hephaestin (HEPH, KIAA0698, UNQ2562/PRO6242)
hephaestin-like protein 1 (HEPHL1)
histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Jumonji AT-rich interactive domain 1b; retinoblastoma-binding protein 2 homolog 1; RBP2-H1 (JARID1B, KDM5B, PLU1, RBBP2H1, PUT1)
hydroxyacid oxidase 1; glycolate oxidase 1 (HAOX1, GOX)
hydroxyacid oxidase 2; (S)-2-hydroxy-acid oxidase, peroxisomal; long chain alpha-hydroxy acid oxidase; long-chain L-2-hydroxy acid oxidase (HAOX2, HAO2)
hydroxyacid-oxoacid transhydrogenase, mitochondrial (HOT, Fe-containing alcohol dehydrogenase, ADHFe1, alcohol dehydrogenase iron-containing protein 1, ADHFE1)
hydroxymethylglutaryl [HMG] CoA reductase (HMGCR)
iodotyrosine dehalogenase 1 (IYD-1, IYD, C6orf71, DEHAL1)
ketone oxidoreductase
L-dopachrome tautomerase; DCT; DT; L-dopachrome delta-isomerase; tyrosinase-related protein 2; TRP-2; TRP2 (DCT, TYRP2)
L-xylulose reductase; XR; carbonyl reductase II; Dicarbonyl/L-xylulose reductase; kidney dicarbonyl reductase; kiDCR; sperm surface protein P34H (DCXR)
lathosterol oxidase; C-5 sterol desaturase; delta(7)-sterol 5-desaturase; lathosterol 5-desaturase; sterol-C5-desaturase (SC5D, SC5DL)
lysine-specific demethylase 4D-like; KDM4D-like protein (KDM4DL, KDM4E)
lysine-specific histone demethylase 1; amine oxidase flavin-containing domain protein 2; BRAF35-HDAC complex protein; BHC110 (AOF2, KDM1A, KIAA0601, LSD1)
Lysyl oxidase homolog 1; Lysyl oxidase-like protein 1; LOL (LOXL1, LOXL)
lysyl oxidase homolog 2 (lysyl oxidase-like protein 2, lysyl oxidase-related protein 2, lysyl oxidase-related protein WS9-14, LOXL2)
lysyl oxidase homolog 3 (lysyl oxidase-like protein 3, LOXL3, LOXL)
lysyl oxidase homolog 4 (lysyl oxidase-like protein 4, lysyl oxidase-related protein C, LOXL4, LOXC)
marginal zone B- & B1-cell-specific protein; mesenteric estrogen-dependent adipose 7; MEDA-7; plasma cell-induced resident endoplasmic reticulum protein; plasma cell-induced resident ER protein; pERp1; proapoptotic caspase adapter protein (MZB1, MEDA7, PACAP, HSPC190)
membrane copper amine oxidase (semicarbazide-sensitive amine oxidase, SSAO, vascular adhesion protein 1, VAP-1, human placenta amine oxidase, HPAO, AOC3, VAP1)
metalloreductase STEAP3 (six-transmembrane epithelial antigen of prostate 3, tumor suppressor-activated pathway protein 6, hTSAP6, pHyde, hpHyde, Dudulin-2, STEAP3, TSAP6)
metalloreductase STEAP4; six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; tumor necrosis factor; alpha-induced protein 9 (STEAP4, STAMP2, TNFAIP9)
methionine synthase reductase, mitochondrial (MSR, MTRR)
methionine-R-sulfoxide reductase B1; MsrB1; selenoprotein X; selX (SEPX1 MSRB1 HSPC270)
methionine-R-sulfoxide reductase B2 (MSRB2, MSRB, CGI-131)
methionine-R-sulfoxide reductase B3, mitochondrial (MsrB3, MSRB3)
mitochondrial peptide methionine sulfoxide reductase; peptide-methionine (S)-S-oxide reductase; peptide Met(O) reductase; protein-methionine-S-oxide reductase; PMSR (MSRA)
MOSC domain-containing protein 1, mitochondrial (MOSC1, MARC1)
MOSC domain-containing protein 2, mitochondrial (MOSC2, MARC2)
NADH-cytochrome b5 reductase FLJ00377 (CYB5RL)
NADPH oxidase
NADPH oxidase 3; mitogenic oxidase 2; MOX-2; gp91phox homolog 3; GP91-3 (NOX3, MOX2)
NADPH oxidase 4; kidney oxidase-1; KOX-1; kidney superoxide-producing NADPH oxidase; renal NADPH-oxidase (NOX4, RENOX)
NADPH-dependent diflavin oxidoreductase 1 (novel reductase 1, NADPH-dependent FMN & FAD containing oxidoreductase, NDOR1, NR1)
nitric oxide [NO] synthase
nucleoredoxin (NXN, NRX)
oxidoreductase C10orf33 (C10orf33, PYROXD2)
oxidoreductase HTATIP2 (HIV-1 TAT-interactive protein 2, 30 kD HIV-1 TAT-interacting protein, HTATIP2, CC3, TIP30)
oxidoreductase KIAA1576 (VAT1L)
oxidoreductase NAD-binding domain-containing protein 1 (OXNAD1)
oxygenase
peroxidase
peroxisomal sarcosine oxidase; PSO; L-pipecolate oxidase; L-pipecolic acid oxidase (PIPOX, LPIPOX, PSO)
phytanoyl-CoA dioxygenase domain-containing protein 1 (PHYHD1)
phytanoyl-CoA dioxygenase, peroxisomal; phytanic acid oxidase; phytanoyl-CoA alpha-hydroxylase; phyH (PHYH, PAHX)
prenylcysteine oxidase 1; prenylcysteine lyase (PCYOX1, KIAA0908, PCL1, UNQ597/PRO1183)
Prenylcysteine oxidase-like (PCYOX1L)
protein disulfide isomerase (cellular thyroid hormone binding protein, prolyl 4-hydroxylase subunit beta, P4HB, ERBA2L, PDI, PDIA1, PO4DB)
protein disulfide reductase (GSH); GSH insulin transhydrogenase
protoporphyrinogen oxidase; PPO (PPOX)
pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (PYROXD1)
pyridoxamine 5'-phosphate oxidase
pyridoxine-5'-phosphate oxidase; pyridoxamine-phosphate oxidase (PNPO)
pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1 (PYCR1)
pyrroline-5-carboxylate reductase 2; P5CR 2; P5C reductase 2 (PYCR2)
pyrroline-5-carboxylate reductase 3 (P5CR 3, P5C reductase 3, pyrroline-5-carboxylate reductase-like protein, PYCRL)
pyrroline-5-carboxylate reductase-like protein C14orf148 (NOXRED1)
quinone oxidoreductase-like 1; protein 4P11; quinone oxidoreductase homolog 1; QOH-1; Zeta-crystallin homolog (CRYZL1, 4P11)
quinone reductase
radical S-adenosyl methionine domain-containing protein 1, mitochondrial (oxygen-independent coproporphyrinogen III oxidase-like protein RSAD1, RSAD1)
ribonucleoside-diphosphate reductase subunit M2 B; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2 (RRM2B, P53R2)
ribonucleotide reductase
sepiapterin reductase; 7,8-dihydrobiopterin:NADP+oxidoreductase (SPR)
shikimate kinase
spermine oxidase; polyamine oxidase 1; PAO-1; PAOh1 (SMOX, C20orf16, SMO, UNQ3039/PRO9854)
sphingolipid delta(4)-desaturase DES1 (degenerative spermatocyte homolog 1, membrane lipid desaturase, migration-inducing gene 15 protein, DEGS1, DES1, MLD, MIG15)
sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 (degenerative spermatocyte homolog 2, DEGS2)
squalene synthetase (farnesyl-diphosphate farnesyltransferase, FDFT1, SQS)
sulfhydryl oxidase 1; hQSOX; quiescin Q6 (QSOX1 QSCN6 UNQ2520/PRO6013)
sulfhydryl oxidase 2; neuroblastoma-derived sulfhydryl oxidase; quiescin Q6-like protein 1 (QSOX2, QSCN6L1, SOXN)
Sulfide:quinone oxidoreductase, mitochondrial (SQRDL)
Sulfiredoxin-1 (EC 1.8.98.2) (SRXN1 C20orf139 SRX)
sulfite oxidase, mitochondrial (SUOX)
superoxide dismutase
thioredoxin domain-containing protein 12; endoplasmic reticulum resident protein 18; ER protein 18; ERp18; endoplasmic reticulum resident protein 19; ER protein 19; ERp19; thioredoxin-like protein p19; hTLP19 (TXNDC12, TLP19, UNQ713/PRO1376)
thioredoxin reductase 1, cytoplasmic; TR; gene associated with retinoic & interferon-induced mortality 12 protein; GRIM-12; gene associated with retinoic & IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; thioredoxin reductase TR1 (TXNRD1, GRIM12, KDRF)
thioredoxin reductase 2, mitochondrial; selenoprotein Z; selZ; TR-beta; thioredoxin reductase TR3 (TXNRD2, KIAA1652, TRXR2)
thioredoxin reductase 3 (thioredoxin reductase TR2, thioredoxin & glutathione reductase, TXNRD3, TGR, TRXR3)
thioredoxin-1 (TRX)
thioredoxin-like protein 5; 14 kD thioredoxin-related protein; protein 42-9-9 (TXNL5, TRP14, TXNDC17)
thymidylate synthase; TS; TSase (TYMS, TS, OK/SW-cl29)
trans-2-enoyl-CoA reductase, mitochondrial; nuclear receptor-binding factor 1; HsNrbf-1; NRBF-1 (MECR, NBRF1, CGI-63)
transmembrane 7 superfamily member 2 (delta(14)-sterol reductase, C-14 sterol reductase, sterol C14-reductase, delta-14-SR, another new gene 1 protein, sterol reductase SR-1, TM7SF2, ANG1)
tRNA-dihydrouridine synthase 1-like (DUS1L)
tRNA-dihydrouridine synthase 2-like (hDUS2, up-regulated in lung cancer, URLC8, DUS2L, DUS2)
tRNA-dihydrouridine synthase 3-like (DUS3L)
tRNA-dihydrouridine synthase 4-like (PP35, DUS4L)
tumor-associated hydroquinone oxidase; tNOX; cytosolic ovarian carcinoma antigen 1; APK1 antigen [Includes: Hydroquinone [NADH] oxidase; Protein disulfide-thiol oxidoreductase] (COVA1, ENOX2)
urate oxidase
vitamin K epoxide reductase complex (VKOR)
WW domain-containing oxidoreductase; fragile site FRA16D oxidoreductase (WWOX, FOR, WOX1)
Zinc-binding alcohol dehydrogenase domain-containing protein 1 (ZADH1, PTGR2)
General
enzyme