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oxandrolone (Oxandrin)
Indications:
1) hyperlipoproteinemia type 5
2) promoting weight gain afer surgery, chronic infection or trauma
3) relief of bone pain associated with osteoporosis
Contraindications:
1) carcinoma of the prostate
2) hypercalcemia (anabolic steroids may stimulate osteolytic bone resorption)
3) pregnancy
4) nephrosis/nephrotic phase of nephritis
Dosage: 2.5 mg BID-QID
Tabs: 2.5 mg
Monitor:
1) liver function tests
2) lipid panel
3) complete blood count
Adverse effects:
1) peliosis hepatis
2) cholestatic hepatitis
3) hepatocellular neoplasms with long-term use
4) skin: acne
5) hair: hirsuitism & male balding pattern in females
6) premature closure of epiphyses in children
7) habituation
8) nausea/vomiting
9) polycythemia
Interactions
drug adverse effects (more general classes)
General
androgen or anabolic steroid
anti-hyperlipidemic agent
Properties
MISC-INFO: elimination route LIVER
pregnancy-category X
safety in lactation ?
Database Correlations
PUBCHEM cid=5878
References
- Journal Watch 20(3): 27, 2000 (Feb 1)
N Eng J Med 341:1966, 1999
- Journal Watch 21(17):140, 2001
Milgrom et al Pediatrics 108:e36, 2001
- Deprecated Reference