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Teashirt homolog 2; ovarian cancer-related protein 10-2; OVC10-2; zinc finger protein 218 (TSHZ2, C20orf17, TSH2, ZNF218)
Function:
- probable transcriptional regulator involved in developmental processes
- may act as a transcriptional repressor
- sumoylated
- interacts (via homeobox domain) with APBB1 (via 1st PID domain) (putative)
Structure:
- belongs to the teashirt C2H2-type Zn+2-finger protein family
- contains 5 C2H2-type Zn+2 fingers
- contains 1 homeobox DNA-binding domain
Compartment: nucleus (probable)
Expression:
- expressed in brain
Pathology:
- strongly reduced in post-mortem elderly subjects with Alzheimer disease
General
C2H2 type zinc finger protein
nuclear protein
Properties
SIZE: entity length = 1034 aa
MW = 115 kD
COMPARTMENT: cell nucleus
MOTIF: coiled coil {13-38}
Zn finger C2H2-type
SITE: 215-239
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 275-299
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 380-404
EFFECTOR-BOUND: Zn+2
homeodomain
SITE: 841-911
Zn finger C2H2-type
SITE: 926-948
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 994-1017
EFFECTOR-BOUND: Zn+2
Database Correlations
UniProt Q9NRE2
LOCUS-LINK correlations
Kegg hsa:128553
References
UniProt :accession Q9NRE2