Otogelin (OTOG OTGN)

Function: - glycoprotein specific to acellular membranes of inner ear - may be required for the anchoring of the otoconial membranes & cupulae to the underlying neuroepithelia in the vestibule - may be involved in the organization &/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea - may play a role in mechanotransduction processes (putative) - Structure: - N-glycosylated (putative), not O-glycosylated - contains 1 CTCK (C-terminal cystine knot-like) domain - contains 1 EGF-like domain - contains 1 TIL (trypsin inhibitory-like) domain - contains 4 VWFD domains Compartment: - apical cell membrane, extracellular side - secreted, extracellular space - localized in acellular membranes covering the sensory epithelial patches of the inner ear: a) cochlea (the auditory sensory organ) b) tectorial membrane over the organ of Corti c) vestibule (the balance sensory organ) d) otoconial membranes over the utricular & saccular maculae e) cupulae over the cristae ampullares of the 3 semi-circular canals - found in fiber-like structures during the maturation process of the tectorial membrane Alternative splicing: named isoforms=2

Properties

SIZE: entity length = 2924 aa MW = 315 kD MOTIF: signal sequence {1-22} EGF domain {101-138} MOTIF: cysteine residue {C105} MODIFICATION: cysteine residue {C119} cysteine residue {C119} MODIFICATION: cysteine residue {C105} cysteine residue {C127} MODIFICATION: cysteine residue {C137} cysteine residue {C137} MODIFICATION: cysteine residue {C127} VWFD domain {150-352} VWFD domain {512-726} TIL {767-831} N-glycosylation site {N913} VWFD domain {984-1186} N-glycosylation site {N1477} proline-rich region SITE: 1481-1879 MOTIF: proline residue (SEVERAL) N-glycosylation site {N1611} VWFD domain {2110-2322} cysteine-rich region {2498-2646} C-terminal cystine knot {2839-2924} MOTIF: cysteine residue {C2839} MODIFICATION: cysteine residue {C2888} cysteine residue {C2853} MODIFICATION: cysteine residue {C2902} cysteine residue {C2864} MODIFICATION: cysteine residue {C2919} cysteine residue {C2868} MODIFICATION: cysteine residue {C2921} cysteine residue {C2888} MODIFICATION: cysteine residue {C2839} cysteine residue {C2902} MODIFICATION: cysteine residue {C2853} cysteine residue {C2919} MODIFICATION: cysteine residue {C2864} cysteine residue {C2921} MODIFICATION: cysteine residue {C2868}

Database Correlations

OMIM 604487 UniProt Q6ZRI0 PFAM correlations

References

UniProt :accession Q6ZRI0