osteomodulin (osteoadherin, OSAD, keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, OMD)

Function: - role in biomineralization processes (putative) - binds osteoblasts via the alpha(V)beta(3)-integrin (putative) - binds keratan sulfate chains (putative) - sulfated on Tyr (putative) Structure: - belongs to the small leucine-rich proteoglycan (SLRP)family, class II subfamily - contains 12 LRR repeats (leucine-rich repeats) Compartment: secreted, extracellular matrix (putative) Expression: bone specific

General

glycoprotein matrix protein

Properties

SIZE: MW = 49 kD entity length = 421 aa COMPARTMENT: extracellular matrix MOTIF: signal sequence {1-20} cysteine-rich region {62-78} leucine-rich repeat SITE: 84-103 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 104-127 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N113} N-glycosylation site {N121} leucine-rich repeat SITE: 128-153 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 154-174 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 175-198 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N187} leucine-rich repeat SITE: 199-224 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 225-245 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N242} leucine-rich repeat SITE: 246-269 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 270-292 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 293-312 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 313-342 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N316} cysteine residue {C321} MODIFICATION: cysteine residue {C353} leucine-rich repeat SITE: 343-367 MOTIF: leucine residue (SEVERAL) cysteine residue {C353} MODIFICATION: cysteine residue {C321} acidic region {385-409} MOTIF: acidic residue (SEVERAL)

Database Correlations

UniProt Q99983 PFAM correlations

References

UniProt :accession Q99983