mimecan; osteoglycin; osteoinductive factor; OIF (OGN, OIF, SLRR3A)

Function: - induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 Structure: - N-glycosylated & O-glycosylated - O-glycosylated with a core 1 glycan or possibly core 8 glycan - belongs to the small leucine-rich proteoglycan (SLRP) family, SLRP class III subfamily - contains 7 LRR repeats (leucine-rich repeats) Compartment: - secreted, extracellular space, extracellular matrix (putative) Expression: bone

General

glycoprotein growth factor leucine-rich repeat-containing protein (LRRC) secreted protein

Properties

SIZE: entity length = 298 aa MW = 34 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-20} Thr glycosylation site {T80} cysteine-rich region {94-106} leucine-rich repeat SITE: 112-131 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 132-155 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 156-179 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 180-199 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 200-225 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N214} leucine-rich repeat SITE: 226-246 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 247-277 MOTIF: leucine residue (SEVERAL) cysteine residue {C255} MODIFICATION: cysteine residue {C288} N-glycosylation site {N258} cysteine residue {C288} MODIFICATION: cysteine residue {C255}

Database Correlations

OMIM 602383 UniProt P20774 Entrez Gene 4969 Kegg hsa:4969

References

UniProt :accession P20774