osteoclast-stimulating factor 1 (OSTF1)

Function: - induces bone resorption, acting probably through a signaling cascade which results in secretion of factor(s) enhancing osteoclast formation & activity - interacts with SRC & SMN1 Structure: - the SH3 domain mediates interaction with SMN1 - contains 3 ANK repeats - contains 1 SH3 domain Compartment: cytoplasm (probable) Expression: - ubiquitously expressed - present in osteoclasts (at protein level)

General

ankyrin repeat domain protein (ANKRD) phosphoprotein

Properties

SIZE: entity length = 214 aa MW = 24 kD COMPARTMENT: cytoplasm MOTIF: proline-rich region SITE: 4-11 MOTIF: proline residue (SEVERAL) src homology 3 [SH3] domain SITE: 12-71 ankyrin repeat NAME: ankyrin repeat SITE: 72-101 ankyrin repeat NAME: ankyrin repeat SITE: 105-135 ankyrin repeat NAME: ankyrin repeat SITE: 139-168 Thr phosphorylation site {T200} Ser phosphorylation site {S202} Ser phosphorylation site {S213}

Database Correlations

OMIM 610180 UniProt Q92882 PFAM correlations Entrez Gene 26578 Kegg hsa:26578

References

UniProt :accession Q92882