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osteocalcin gene
1q25-q31
Structure:
- AP1-site within Retinoic Acid Response Element (RARE)
Expression:
- binding of AP1 to osteocalcin gene inhibits retinoic acid induced expression of osteocalcin
- binding of the glucocorticoid receptor to GRE inhibits expression of osteocalcin
Related
osteocalcin; bone GLA protein; gamma-carboxyglutamic acid-containing protein (BGP, BGLAP)
General
gene with TATA box
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: osteocalcin
MOTIF: tumor necrosis factor [TNF] response element
SITE: -522 to -511
MOTIF-SEQUENCE: AGGCTGCCT
vitamin D response element (VDRE)
SITE: -462 to -440
MOTIF: AP1 site
NAME: AP1 site
osteocalcin box
SITE: -99 to -76
MOTIF: CCAAT box
NUCLEOTIDE-SEQUENCE: consensus
glucocorticoid response element
NAME: glucocorticoid response element
SITE: ? to -30
TATA box
NAME: TATA box
transcriptional start site
exon
intron
transcriptional termination site
Database Correlations
Entrez Gene 632
References
- Hunter T.
Cooperation between oncogenes.
Cell. 1991 Jan 25;64(2):249-70. Review.
PMID: 1988147