orphan nuclear receptor NR6A1 (nuclear receptor subfamily 6 group A member 1, germ cell nuclear factor, GCNF, retinoid receptor-related testis-specific receptor, RTR, NR6A1, GCNF)

Function: - orphan nuclear receptor - binds to a response element containing the sequence 5'-TCAAGGTCA-3' - may be involved in regulation of gene expression in germ cell development during gametogenesis - interacts with RXRIP110 Structure: - homodimer - belongs to the nuclear hormone receptor family, NR6 subfamily - contains 1 nuclear receptor DNA-binding domain Compartment: nucleus Alternative splicing: named isoforms=3 Expression: highest expression in germ cells of adult testis

General

nuclear hormone receptor family orphan receptor testis-specific protein zinc finger protein

Properties

SIZE: MW = 54 kD entity length = 480 aa COMPARTMENT: cytoplasm MOTIF: DNA-binding motif SITE: 57-132 MOTIF: Zn finger C4-type SITE: 60-80 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 96-120 EFFECTOR-BOUND: Zn+2 binding site SITE: 172-253 FOR-BINDING-OF: retinoid X receptor-interacting protein 110

Database Correlations

OMIM 602778 UniProt Q15406 PFAM correlations Kegg hsa:2649

References

UniProt :accession Q15406