orphan nuclear receptor NR2E1 (nuclear receptor subfamily 2 group E member 1, nuclear receptor TLX, tailless homolog, Tll, hTll, NR2E1, TLX)

Function: 1) orphan receptor 2) binds DNA as a monomer a) binds to hormone response elements (HRE) containing extended core motif half-site sequence 5'-AAGGTCA-3' b) 5' flanking nucleotides participate in determining receptor specificity 3) brain development (putative) 4) retinal development (putative) Structure: - monomer - belongs to the nuclear hormone receptor family, NR2 subfamily - contains 1 nuclear receptor DNA-binding domain Compartment: nucleus Expression: - brain specific - highest levels in the caudate nucleus & hippocampus - weakest levels in thalamus

General

nuclear hormone receptor family orphan receptor zinc finger protein

Properties

SIZE: MW = 43 kD entity length = 385 aa COMPARTMENT: cytoplasm MOTIF: DNA-binding motif SITE: 13-90 MOTIF: Zn finger C4-type SITE: 16-36 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 52-78 EFFECTOR-BOUND: Zn+2 binding site SITE: 187-354 FOR-BINDING-OF: ligand

Database Correlations

OMIM 603849 UniProt Q9Y466 PFAM correlations Kegg hsa:7101

References

UniProt :accession Q9Y466