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orphan nuclear receptor NR1D2; nuclear receptor subfamily 1 group D member 2; Rev-erb-beta; EAR-1R; rev-erbA-alpha-related receptor; orphan nuclear hormone receptor BD73; rev-erb (NR1D2, RVR)
Function:
1) binds to the sequences 5'-AATGTAGGTCA-3' & 5'-ATAACTAGGTCA-3'
2) potent competitive repressor of ROR alpha
3) interacts with NCOA5 coactivator, increasing transcription of target genes
Structure:
- belongs to the nuclear hormone receptor family, NR1 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment: nucleus
Comparative biology:
- activation of Rev-erb with SR9009 led to increased metabolic activity in skeletal muscle of mice
- treated mice had a 50% increase in running time & distance [2]
Related
nuclear receptor subfamily 1 group D member 1; Rev-erbA-alpha; V-erbA-related protein 1; EAR-1 (NR1D1, EAR1, HREV, THRAL)
General
nuclear hormone receptor family
orphan receptor
zinc finger protein
Properties
SIZE: MW = 65 kD
entity length = 579 aa
COMPARTMENT: cytoplasm
MOTIF: serine-rich region {13-20}
MOTIF: serine residue (SEVERAL)
serine-rich region {35-39}
MOTIF: serine residue (SEVERAL)
DNA-binding motif
SITE: 100-176
MOTIF: Zn finger C4-type
SITE: 103-123
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 140-164
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 602304
UniProt Q14995
PFAM correlations
Entrez Gene 9975
Kegg hsa:9975
References
- UniProt :accession Q14995
- Woldt E, Sebti Y, Solt LA et al
Rev-Erb Modulates Skeletal Muscle Oxidative Capacity by
Regulating Mitochondrial Biogenesis and Autophagy.
Nat Med. 2013 Jul 14
PMID: 23852339