ornithine decarboxylase antizyme 3; AZ3; ODC-Az 3 (OAZ3)

Function: - binds to, & destabilizes, ornithine decarboxylase - does not accelerate ornithine decarboxylase degeneration - OAZ3 probably plays a role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells - interacts with GGN (putative) Structure: belongs to the ODC antizyme family Compartment: - nucleus, cytoplasm (putative) Expression: - testis specific - expression starts early in spermiogenesis & terminates in late spermatid phase Miscellaneous: - aribosomal frameshift occurs between the codons for Ser-28 & Glu-29 - an autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines

Related

antizyme inhibitor 1; AZI; ornithine decarboxylase antizyme inhibitor (AZIN1, OAZI, OAZIN) ornithine decarboxylase 1

General

nuclear protein ornithine decarboxylase antizyme testis-specific protein

Properties

SIZE: entity length = 187 aa MW = 21 kD COMPARTMENT: cytoplasm cell nucleus

Database Correlations

OMIM 605138 UniProt Q9UMX2 Pfam PF02100 Entrez Gene 51686 Kegg hsa:51686

References

UniProt :accession Q9UMX2