origin recognition complex subunit 6 (ORC6L, ORC6)

Function: - component of the origin recognition complex (ORC) that binds origins of replication - role in both chromosomal replication & mating type transcriptional silencing - binds to the ARS consensus sequence of origins of replication (ATP-dependent) - interacts with DBF4 - phosphorylated upon DNA damage, probably by ATM or ATR Structure: belongs to the ORC6 family Compartment: nucleus

General

nuclear protein phosphoprotein protein subunit

Properties

SIZE: entity length = 252 aa MW = 28 kD COMPARTMENT: cell nucleus MOTIF: Thr phosphorylation site {T195} Thr phosphorylation site {T229}

Database Correlations

OMIM 607213 UniProt Q9Y5N6 Pfam PF05460 Kegg hsa:2359

References

UniProt :accession Q9Y5N6