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solute carrier family 22 member 3; organic cation transporter 3; extraneuronal monoamine transporter; EMT (SLC22A3, EMTH, OCT3)
Function:
- mediates potential-dependent transport of a variety of organic cations
- may play a significant role in the disposition of cationic neurotoxins & neurotransmitters in the brain
Structure:
- belongs to the major facilitator superfamily, organic cation transporter family
Compartment: membrane
Expression:
- expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney & brain cortex
- no expression detected in spleen
General
glycoprotein
major facilitator superfamily (MFS)
solute carrier family 22 (SLC22, SLC22A)
transmembrane 6 protein
Properties
SIZE: MW = 61 kD
entity length = 556 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {21-41}
N-glycosylation site {N72}
N-glycosylation site {N99}
N-glycosylation site {N119}
cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
LOOP#: 2
exoplasmic loop
LOOP#: 3
transmembrane domain {182-202}
transmembrane domain {241-261}
active site
MOTIF: adenine nucleotide-binding site
ATP-binding site
NAME: ATP-binding site
transmembrane domain {269-289}
N-glycosylation site {N322}
transmembrane domain {381-401}
cytoplasmic domain {C-TERMINAL}
transmembrane domain {468-488}
transmembrane domain {498-518}
Database Correlations
OMIM 604842
UniProt O75751
Pfam PF07690
Kegg hsa:6581
References
UniProt :accession O75751