Search
organic anion transporting polypeptide 1 (Na+ independent organic anion transporter, OATP1, OATP-A, solute carrier family 21 member 3, SLC21A3, SLCO1A2)
Function:
- mediates the Na+-independent transport of organic anions such as sulfobromophthalein (BSP) & conjugated (taurocholate) & unconjugated (cholate) bile acids
Inhibition:
- selectively inhibited by naringin found in grapefruit
Structure:
- belongs to the organo anion transporter (TC 2.A.60) family
- contains 1 Kazal-like domain
Compartment: membrane
Alternative splicing: named isoforms=2
General
glycoprotein
organic anion transporting polypeptide (OATP)
solute carrier family 21 (SLC21, SLC21A)
transmembrane 12e protein
Properties
SIZE: MW = 74 kD
entity length = 670 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-20}
transmembrane domain {21-37}
cytoplasmic loop {38-85}
transmembrane domain {86-106}
exoplasmic loop {107-155}
MOTIF: N-glycosylation site {N124}
N-glycosylation site {N135}
transmembrane domain {156-176}
cytoplasmic loop {177-193}
transmembrane domain {194-214}
exoplasmic loop {215-245}
transmembrane domain {246-266}
cytoplasmic loop {267-315}
transmembrane domain {316-336}
exoplasmic loop {337-355}
transmembrane domain {356-376}
cytoplasmic loop {377-389}
transmembrane domain {390-410}
exoplasmic loop {411-460}
MOTIF: N-glycosylation site {N412}
N-glycosylation site {N419}
transmembrane domain {461-481}
cytoplasmic loop {482-512}
transmembrane domain {513-533}
exoplasmic loop {534-556}
transmembrane domain {557-577}
cytoplasmic loop {578-602}
transmembrane domain {603-623}
exoplasmic domain {624-670}
MOTIF: N-glycosylation site {N632}
Database Correlations
OMIM 602883
UniProt P46721
PFAM correlations
Entrez Gene 6579
Kegg hsa:6579
References
UniProt :accession P46721