opticin (oculoglycan, OPTC, OPT)

Function: - binds collagen fibrils Structure: - O-glycosylated - belongs to the small leucine-rich proteoglycan (SLRP)family, class III subfamily - contains 7 LRR repeats (leucine-rich repeats) Compartment: extracellular matrix Expression: retina, iris, ligament, skin & fetal liver

General

glycoprotein matrix protein

Properties

SIZE: MW = 37 kD entity length = 332 aa COMPARTMENT: extracellular matrix MOTIF: signal sequence {1-19} threonine-rich region {81-112} MOTIF: threonine residue (SEVERAL) cysteine-rich region {128-140} leucine-rich repeat SITE: 146-165 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 166-189 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 190-213 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 214-233 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 234-259 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 260-280 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 281-311 MOTIF: leucine residue (SEVERAL) cysteine residue {C289} MODIFICATION: cysteine residue {C322} N-glycosylation site {N312} cysteine residue {C322} MODIFICATION: cysteine residue {C289}

Database Correlations

OMIM 605127 UniProt Q9UBM4 Pfam PF00560

References

UniProt :accession Q9UBM4