opsin

An opsin pineal or P-opsin is expressed in chick pineal. The sequence of P-opsin suggests it is maximally sensitive to light of approx 500 nm. Light-induced stimulation of P-opsin allegedly induces N-acetyl transferase activity which, in turn, supresses melatonin synthesis. Light stimulation also shifts the phase of the circadian rhythm of melatonin synthesis (entrainment). There are 3 human ospins 1) blue-sensitive opsin 2) green-sensitive opsin 3) red-sensitive opsin

Related

11-cis retinal melatonin pineal gland (body)

Specific

Blue-sensitive opsin; BOP; blue cone photoreceptor pigment (OPN1SW, BCP) green-sensitive opsin; green cone photoreceptor pigment (OPN1MW, GCP) medium-wave-sensitive opsin 2; Opsin 1 cone pigments medium-wave-sensitive 2 (OPN1MW2) medium-wave-sensitive opsin 3; opsin 1 cone pigments medium-wave-sensitive 3 (OPN1MW3) melanopsin; opsin-4 (OPN4, MOP) Opsin-3; encephalopsin; panopsin (OPN3, ECPN) opsin-5 (neuropsin, G-protein coupled receptor 136, G-protein coupled receptor PGR12, transmembrane protein 13, OPN5, GPR136, PGR12, TMEM13) red-sensitive opsin; red cone photoreceptor pigment (OPN1LW, RCP)

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {N-TERMINAL} transmembrane domain {TM1} transmembrane domain {TM2} transmembrane domain {TM3} N-glycosylation site {N4} transmembrane domain {TM4} transmembrane domain {TM5} transmembrane domain {TM6} transmembrane domain {TM7} N-glycosylation site {N11} binding site SITE: C-TERMINAL-CYS EFFECTOR-BOUND: palmitate BOUND-VIA: carboxylate cysteine residue {C104} MODIFICATION: cysteine residue {C181} cysteine residue {C181} MODIFICATION: cysteine residue {C104} lysine residue {K288} MODIFICATION: 11-cis retinal cytoplasmic domain {C-TERMINAL}