one cut domain family member 3 (transcription factor ONECUT-3, OC-3, ONECUT3)

Function: - transcriptional activator - binds consensus DNA sequence 5'-DHWATTGAYTWWD-3' on gene promoters, including HNF3B & TTR genes Structure: - contains 1 CUT DNA-binding domain - contains 1 homeobox DNA-binding domain Compartment: nucleus

General

homeobox protein transcription factor (TF)

Properties

SIZE: MW = 50 kD entity length = 494 aa COMPARTMENT: cell nucleus MOTIF: glycine-rich region {37-315} MOTIF: proline-rich region SITE: 141-247 MOTIF: proline residue (SEVERAL) DNA-binding motif SITE: 312-398 homeodomain SITE: 414-473

Database Correlations

UniProt O60422 PFAM correlations

References

UniProt :accession O60422