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One cut domain family member 2; hepatocyte nuclear factor 6-beta; HNF-6-beta; one cut homeobox 2; transcription factor ONECUT-2; OC-2 (ONECUT2, HNF6B)
Function:
- transcriptional activator
- activates the transcription of a number of liver genes such as HNF3B
Structure:
- belongs to the CUT homeobox family
- contains 1 CUT DNA-binding domain
- contains 1 homeobox DNA-binding domain
Compartment: nucleus
Note:
- uncertain whether Met-1 or Met-20 is the initiator
General
transcription factor (TF)
Properties
SIZE: entity length = 504 aa
MW = 54 kD
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {37-56}
proline-rich region
SITE: 81-85
MOTIF: proline residue (SEVERAL)
alanine-rich region {94-101}
MOTIF: alanine residue (SEVERAL)
histidine-rich region {168-184}
MOTIF: histidine residue (SEVERAL)
serine-rich region {317-322}
MOTIF: serine residue (SEVERAL)
DNA-binding motif
SITE: 324-410
homeodomain
SITE: 426-485
Database Correlations
OMIM 604894
UniProt O95948
PFAM correlations
Entrez Gene 9480
Kegg hsa:9480
References
- UniProt :accession O95948
- Wikipedia; Note: hepatocyte nuclear factors entry
http://en.wikipedia.org/wiki/hepatocyte_nuclear_factors