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one cut domain family member 1; hepatocyte nuclear factor 6; HNF-6; one cut homeobox 1 (ONECUT1, HNF6, HNF6A)
Function:
- transcriptional activator
- binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B & TTR
- important for liver gene transcription
- binds DNA as a monomer (putative)
Structure:
- belongs to the CUT homeobox family
- contains 1 CUT DNA-binding domain
- contains 1 homeobox DNA-binding domain
Compartment: nucleus
Expression:
- highly expressed in liver
- lower expression in testis & skin
General
transcription factor (TF)
Properties
SIZE: entity length = 465 aa
MW = 51 kD
COMPARTMENT: cell nucleus
MOTIF: histidine-rich region {69-72}
MOTIF: histidine residue (SEVERAL)
histidine-rich region {124-138}
MOTIF: histidine residue (SEVERAL)
DNA-binding motif
SITE: 283-369
homeodomain
SITE: 385-444
serine-rich region {455-460}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 604164
UniProt Q9UBC0
PFAM correlations
Entrez Gene 3175
Kegg hsa:3175
References
- UniProt :accession Q9UBC0
- Wikipedia; Note: hepatocyte nuclear factors entry
http://en.wikipedia.org/wiki/hepatocyte_nuclear_factors