Search
Oncostatin-M specific receptor
Function:
1) transduces OSM-specific signaling events
2) heterodimer composed of OSMR & IL6ST
General
molecular complex
receptor
Properties
MOTIF: ligand-binding site
SUBUNITS: oncostatin-M specific receptor subunit beta
MOTIF: signal sequence {1-27}
N-glycosylation site {N163}
cysteine residue {C245}
MODIFICATION: cysteine residue {C255}
cysteine residue {C255}
MODIFICATION: cysteine residue {C245}
N-glycosylation site {N326}
fibronectin type III domain or F3 module {332-424}
MOTIF: N-glycosylation site {N380}
WSXWS motif {415-419}
fibronectin type III domain or F3 module {430-524}
MOTIF: N-glycosylation site {N446}
fibronectin type III domain or F3 module {526-619}
MOTIF: N-glycosylation site {N580}
fibronectin type III domain or F3 module {625-732}
transmembrane domain {741-761}
box1 motif
SITE: 770-778
FOR-BINDING-OF: Janus kinase (JAK)
interleukin-6 receptor subunit beta
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-22}
immunoglobulin superfamily domain {26-120}
MOTIF: cysteine residue {C28}
MODIFICATION: cysteine residue {C54}
N-glycosylation site {N43}
cysteine residue {C48}
MODIFICATION: cysteine residue {C103}
cysteine residue {C54}
MODIFICATION: cysteine residue {C28}
N-glycosylation site {N83}
cysteine residue {C103}
MODIFICATION: cysteine residue {C48}
fibronectin type III domain or F3 module {125-216}
MOTIF: N-glycosylation site {N131}
cysteine residue {C134}
MODIFICATION: cysteine residue {C144}
cysteine residue {C144}
MODIFICATION: cysteine residue {C134}
N-glycosylation site {N157}
cysteine residue {C172}
MODIFICATION: cysteine residue {C182}
cysteine residue {C182}
MODIFICATION: cysteine residue {C172}
fibronectin type III domain or F3 module {222-321}
MOTIF: N-glycosylation site {N227}
WSXWS motif {310-314}
fibronectin type III domain or F3 module {326-418}
MOTIF: N-glycosylation site {N379}
N-glycosylation site {N383}
fibronectin type III domain or F3 module {423-514}
MOTIF: cysteine residue {C458}
MODIFICATION: cysteine residue {C466}
cysteine residue {C466}
MODIFICATION: cysteine residue {C458}
fibronectin type III domain or F3 module {518-610}
MOTIF: N-glycosylation site {N553}
N-glycosylation site {N564}
transmembrane domain {620-641}
box1 motif
SITE: 651-659
FOR-BINDING-OF: Janus kinase (JAK)
Ser phosphorylation site {S667}
serine-rich region {725-755}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S782}
Ser phosphorylation site {S820}
Ser phosphorylation site {S829}
References
UniProt :accession Q99650
Components
CD130; gp130; interleukin-6 receptor subunit beta; IL-6R-beta; interleukin-6 signal transducer; membrane glycoprotein 130; CDw130; oncostatin-M receptor alpha subunit (IL6ST)
oncostatin-M specific receptor subunit beta (OSMR, OSMRB)