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oncoprotein-induced transcript 3 protein (liver-specific zona pellucida domain-containing protein, OIT3, LZP, UNQ826/PRO1753)
Function:
- may be involved in hepatocellular function & development
Structure:
- contains 1 EGF-like domain
- contains 1 ZP domain
Compartment:
- nuclear envelope
- can be secreted into blood
Alternative splicing: named isoforms=2
Expression:
- liver-specific
- expressed only in hepatocytes
Pathology:
- down-regulated in hepatocellular carcinoma (HCC) & HCC cell lines
General
glycoprotein
nuclear protein
Properties
SIZE: entity length = 545 aa
MW = 60 kD
COMPARTMENT: cell nucleus
MOTIF: signal sequence {1-22}
N-glycosylation site {N89}
N-glycosylation site {N116}
EGF domain {182-222}
MOTIF: cysteine residue {C186}
MODIFICATION: cysteine residue {C197}
cysteine residue {C193}
MODIFICATION: cysteine residue {C206}
cysteine residue {C197}
MODIFICATION: cysteine residue {C186}
cysteine residue {C206}
MODIFICATION: cysteine residue {C193}
cysteine residue {C208}
MODIFICATION: cysteine residue {C221}
cysteine residue {C221}
MODIFICATION: cysteine residue {C208}
ZP domain {261-516}
MOTIF: cysteine residue {*1}
MODIFICATION: cysteine residue {*2}
cysteine residue {*2}
MODIFICATION: cysteine residue {*1}
N-glycosylation site {N299}
Database Correlations
UniProt Q8WWZ8
PFAM correlations
References
UniProt :accession Q8WWZ8