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olpasiran
Mechanism of action: - reduces lipoprotein(a) synthesis in the liver [1]General
short interfering double-stranded RNA; antisense oligonucleotide (siRNA, microRNA, miRNA)References
- O'Donoghue ML, Rosenson RS, Gencer B et al Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease. N Engl J Med. 2022. Nov 6 PMID: 36342163 https://www.nejm.org/doi/full/10.1056/NEJMoa2211023