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olopatadine (Patanol, Pataday)
Tradenames: Patanol.
Indications:
- hayfever, allergic rhinitis, allergic conjunctivitis
Dosage: 1-2 drops QD, BID
Ophthalmic: 0.1% (Pataday) BID, 0.7% QD Nasal spray 0.4%, 0.6%
Mechanism of action:
- ophthalmic antihistamine with mast cell-stabilizing properties
Interactions
drug adverse effects of H1 receptor antagonists
General
H1 receptor antagonist (antihistamine)
ocular decongestant
Properties
MISC-INFO: elimination route KIDNEY
pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- Kamis U, Ozturk BT, Ozkagnici A, Gunduz K.
Comparison of the efficacy of olopatadine hydrochloride 0.1%
ophthalmic solution and artificial tears in seasonal allergic
conjunctivitis.
Acta Ophthalmol Scand. 2006 Feb;84(1):148-9.
PMID: 16445458
- Meltzer EO, Hampel FC, Ratner PH, Bernstein DI, Larsen LV,
Berger WE, Finn AF Jr, Marple BF, Roland PS, Wall GM,
Brubaker MJ, Dimas C, Potts SL, Silver LH, Barnes JR.
Safety and efficacy of olopatadine hydrochloride nasal
spray for the treatment of seasonal allergic rhinitis.
Ann Allergy Asthma Immunol. 2005 Dec;95(6):600-6.
PMID: 16400902
- Hampel FC Jr, Ratner PH, Amar NJ, van Bavel JH, Mohar D,
Fairchild CJ, Wall GM, Brubaker MJ, Drake M, Crenshaw KM.
Improved quality of life among seasonal allergic rhinitis
patients treated with olopatadine HCl nasal spray 0.4% and
olopatadine HCl nasal spray 0.6% compared with vehicle placebo.
Allergy Asthma Proc. 2006 May-Jun;27(3):202-7.
PMID: 16913262
- Prescriber's Letter 15(6): 2008
Nasal Sprays for Allergic Rhinitis
Detail-Document#: 240609
(subscription needed) http://www.prescribersletter.com