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oligodendrocyte transcription factor 2; oligo2; class B basic helix-loop-helix protein 1; bHLHb1; class E basic helix-loop-helix protein 19; bHLHe19; protein kinase C-binding protein RACK17; protein kinase C-binding protein 2 (OLIG2, BHLHB1, BHLHE19, PRKCBP2, RACK17)

Function: - required for oligodendrocyte & motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain - cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube antagonist of V2 interneuron & of NKX2-2-induced V3 interneuron development (putative) - interacts with NKX2-2 (putative) Structure: - the bHLH is essential for interaction with NKX2-2 - contains 1 basic helix-loop-helix (bHLH) domain Compartment: - nucleus (putative), cytoplasm - the NLS contained in the bHLH domain could be masked in the native form & translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2 Expression: - expressed in the brain, in oligodendrocytes - strongly expressed in oligodendrogliomas - expression is weak to moderate in astrocytomas - expression in glioblastomas highly variable - induced by SHH. - also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (putative) Pathology: - expressed in oligodendroglial tumors of brain - chromosomal translocation t(14;21)(q11.2;q22) involving OLIG2 with TCRA may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL) [4]

General

basic helix loop helix (bHLH) family transcription factor

Properties

SIZE: entity length = 323 aa MW = 32 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: serine-rich region {77-88} MOTIF: serine residue (SEVERAL) DNA-binding motif SITE: 109-120 helix-loop-helix NAME: helix-loop-helix SITE: 121-162 FOR-BINDING-VIA: helix-loop-helix alanine-rich region {206-212} MOTIF: alanine residue (SEVERAL) alanine-rich region {225-237} MOTIF: alanine residue (SEVERAL) alanine-rich region {266-270} MOTIF: alanine residue (SEVERAL) glycine-rich region {273-280}

Database Correlations

OMIM 606386 UniProt Q13516 Pfam PF00010 Entrez Gene 10215 Kegg hsa:10215

References

  1. UniProt :accession Q13516
  2. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/OLIG2ID236.html
  3. Arnett HA et al bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science. 2004 Dec 17;306(5704):2111-5. PMID: 15604411
  4. Wang J et al The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3497-502. PMID: 10737801