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oligodendrocyte transcription factor 1; oligo1; class B basic helix-loop-helix protein 6; bHLHb6; class E basic helix-loop-helix protein 21; bHLHe21 (OLIG1, BHLHB6, BHLHE21)
Function:
- promotes formation & maturation of oligodendrocytes, especially within the brain
- cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (putative)
Structure:
- contains 1 basic helix-loop-helix (bHLH) domain
Compartment:
- nucleus
- in neonatal mice, olig1 localized to the nucleus in oligodencrocytes, but became more cytoplasmic after week 2 & was entirely cytoplasmic in white matter in the adult
Expression:
- expressed in the brain
- expressed in myelinating oligodendrocytes & oligodendrocyte progenitors in developing CNS & mature oligodendrocytes
- strongly expressed in oligodendrogliomas
- expression is weak to moderate in astrocytomas
- expression in glioblastomas is highly variable
General
basic helix loop helix (bHLH) family transcription factor
Properties
SIZE: entity length = 271 aa
MW = 28 kD
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {43-59}
MOTIF: serine residue (SEVERAL)
glutamine-rich region {102-105}
MOTIF: glutamine residue (SEVERAL)
DNA-binding motif
SITE: 106-115
helix-loop-helix
NAME: helix-loop-helix
SITE: 116-164
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 606385
UniProt Q8TAK6
Pfam PF00010
Entrez Gene 116448
Kegg hsa:116448
References
- Arnett HA et al
bHLH transcription factor Olig1 is required to repair
demyelinated lesions in the CNS.
Science 306:2111-5, 2004
PMID: 156044112
- UniProt :accession Q8TAK6