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olfactory receptor 51E1; prostate overexpressed G protein-coupled receptor; prostate-specific G protein-coupled receptor 2; G-protein coupled receptor 164; D-GPCR (OR51E1 GPR164 OR51E1P OR52A3P POGR PSGR2)
Function: odorant receptor (putative)
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- highly expressed in prostate
- very low levels detected in other tissues, including: placenta, skeletal muscle, heart, ovary & testis
Pathology: up-regulated in prostate cancers
General
glycoprotein
olfactory receptor, family 51
Properties
SIZE: entity length = 317 aa
MW = 35 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-27}
MOTIF: N-glycosylation site {N7}
transmembrane domain {28-48}
cytoplasmic loop {49-56}
transmembrane domain {57-77}
exoplasmic loop {78-101}
MOTIF: N-glycosylation site {N90}
cysteine residue {C99}
MODIFICATION: cysteine residue {C191}
transmembrane domain {102-122}
cytoplasmic loop {123-141}
transmembrane domain {142-162}
exoplasmic loop {163-198}
MOTIF: cysteine residue {C191}
MODIFICATION: cysteine residue {C99}
transmembrane domain {199-219}
cytoplasmic loop {220-238}
transmembrane domain {239-259}
exoplasmic loop {260-274}
transmembrane domain {275-295}
cytoplasmic domain {296-317}
Database Correlations
OMIM 611267
UniProt Q8TCB6
Pfam PF00001
Entrez Gene 81286
Kegg hsa:1435
References
- UniProt :accession Q8TCB6
- Human olfactory receptor Data exploratorium (HORDE)
http://bip.weizmann.ac.il/cgi-bin/HORDE/showgene.pl?key=symbol&value=OR51E1