Search
olfactory receptor 4A8 (olfactory receptor OR11-110, OR4A8P, OR4A8)
Function: odorant receptor (putative)
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Polymorphism:
- a stop codon in the gene coding for OR4A8P at position Arg-136 is responsible for functional diversity producing thus a pseudogene.
- the stop codon is more frequent in African-Americans than in non-Africans
General
glycoprotein
olfactory receptor, family 4
Properties
SIZE: entity length = 315 aa
MW = 36 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-24}
MOTIF: N-glycosylation site {N6}
transmembrane domain {25-45}
cytoplasmic loop {46-57}
transmembrane domain {58-80}
exoplasmic loop {81-95}
MOTIF: cysteine residue {C95}
MODIFICATION: cysteine residue {C177}
transmembrane domain {96-116}
cytoplasmic loop {117-139}
transmembrane domain {140-160}
exoplasmic loop {161-193}
MOTIF: cysteine residue {C177}
MODIFICATION: cysteine residue {C95}
transmembrane domain {194-214}
cytoplasmic loop {215-235}
transmembrane domain {236-256}
exoplasmic loop {257-266}
transmembrane domain {267-287}
cytoplasmic domain {288-315}
Database Correlations
UniProt P0C604
References
- UniProt :accession P0C604
- Human olfactory receptor Data exploratorium (HORDE)
http://bip.weizmann.ac.il/cgi-bin/HORDE/showgene.pl?key=symbol&value=OR4A8P