Search
olfactory receptor 11H7 (olfactory receptor OR14-32, OR11H7P, OR11H7)
Function: odorant receptor, activated by isovaleric acid
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Polymorphism:
- a stop codon in the gene coding for OR11H7P at position Gln-227 is responsible for functional diversity producing thus a pseudogene
- hypersensitivity towards isovaleric acid is seen predominantly in individuals who carry at least one copy of the intact allele
General
glycoprotein
olfactory receptor, family 11
Properties
SIZE: entity length = 314 aa
MW = 35 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-24}
MOTIF: N-glycosylation site {N2}
transmembrane domain {25-45}
cytoplasmic loop {46-57}
transmembrane domain {58-78}
exoplasmic loop {79-97}
MOTIF: cysteine residue {C97}
MODIFICATION: cysteine residue {C179}
transmembrane domain {98-118}
cytoplasmic loop {119-142}
transmembrane domain {143-163}
exoplasmic loop {164-201}
MOTIF: cysteine residue {C179}
MODIFICATION: cysteine residue {C97}
transmembrane domain {202-222}
cytoplasmic loop {223-244}
transmembrane domain {245-265}
exoplasmic loop {266-271}
transmembrane domain {272-292}
cytoplasmic domain {293-314}
Database Correlations
UniProt Q8NGC8
Pfam PF00001
References
- UniProt :accession Q8NGC8
- Human olfactory receptor Data exploratorium (HORDE)
http://bip.weizmann.ac.il/cgi-bin/HORDE/showgene.pl?key=symbol&value=OR11H7P