olfactomedin-4 (OLM4, G-CSF-stimulated clone 1 protein, hGC-1, hOLfD, antiapoptotic protein GW112, OLFM4, GW112, UNQ362/PRO698)

Function: - antiapoptotic factor - promotes tumor growth - promotes proliferation of pancreatic cancer cells by favoring transition from the S to G2/M phase - facilitates cell adhesion - interacts with NDUFA13 - interacts with cell surface lectins (locutions ricinus communis agglutinin I, concanavalin A & wheat germ agglutinin) & cadherin Structure: - homomultimer, disulfide-linked, N-glycosylated - olfactomedin-like domain is involved in the interaction with cadherin - contains 1 olfactomedin-like domain Compartment: - secreted, extracellular space - may be found in mitochondrion & nucleus Expression: - expressed during myeloid lineage development - expressed in the prostate, small intestine & colon > bone marrow & stomach - elevated expression during early S phase of cell cycle Paathology: - highly expressed in pancreatic cancer tissues - also expressed at high levels in stomach cancer & colon cancer

General

glycoprotein secreted protein

Properties

SIZE: entity length = 510 aa MW = 57 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-20} serine-rich region {31-71} MOTIF: serine residue (SEVERAL) N-glycosylation site {N72} N-glycosylation site {N136} coiled coil {155-234} Olfactomedin-like {245-507} MOTIF: cysteine residue {C246} MODIFICATION: cysteine residue {C437} N-glycosylation site {N253} cysteine residue {C437} MODIFICATION: cysteine residue {C246}

Database Correlations

UniProt Q6UX06 Pfam PF02191

References

UniProt :accession Q6UX06