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POU domain, class 3, transcription factor 1; octamer-binding protein 6; Oct-6; octamer-binding transcription factor 6; OTF-6; POU domain transcription factor SCIP (POU3F1, OCT6, OTF6)
A transcriptional repressor of myelin-specific genes, expressed in dividing schwann cells.
Function:
- transcription factor & DNA-binding protein
- binds to the octamer motif 5'-ATTTGCAT-3'
- role in early embryogenesis & neurogenesis (putative)
Structure:
- belongs to the POU transcription factor family, class- 3 subfamily
- contains 1 homeobox DNA-binding domain
- contains 1 POU-specific domain
Compartment: nucleus
Expression:
- expressed in embryonal stem cells & in the developing brain
General
octamer transcription factor
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 451 aa
MW = 45 kD
COMPARTMENT: cell nucleus
MOTIF: alanine-rich region {27-45}
MOTIF: alanine residue (SEVERAL)
glycine-rich region {59-242}
MOTIF: alanine-rich region {225-228}
MOTIF: alanine residue (SEVERAL)
POU domain
SITE: 247-321
homeodomain
SITE: 339-398
glycine-rich region {418-423}
proline-rich region
SITE: 430-435
MOTIF: proline residue (SEVERAL)
histidine-rich region {439-444}
MOTIF: histidine residue (SEVERAL)
Database Correlations
OMIM 602479
UniProt Q03052
PFAM correlations
Entrez Gene 5453
Kegg hsa:5453
References
- Monuki ES, Kuhn R, Weinmaster G, Trapp BD, Lemke G.
Expression and activity of the POU transcription factor SCIP.
Science. 1990 Sep 14;249(4974):1300-3.
PMID: 1975954
- UniProt :accession Q03052