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ochronosis

Etiology: 1) pathological condition in certain patients with alkaptonuria 2) hydroquinone [2] Pathology: -> cartilage degeneration results osteoarthritis & chondrocalcinosis, particularly of the spine Clinical manifestations: 1) pigmentation of cartilage 2) pigmentation of other tissues may occur a) muscle b) epithelial cells c) dense connective tissue 3) pigmentation of: a) sclera b) mucous membrane of the lips c) skin of the ears, face & hands Laboratory: - standing urine is dark in color & contains pigmented* casts * pigmentation occurs secondary to oxidation of homogentisic acid

Interactions

disease interactions

Related

alkaptonuria homogentisate

General

arthritis

References

  1. Stedman's Medical Dictionary 26th ed, Williams & Wilkins, Baltimore, 1995
  2. Prescriber's Letter 13(10): 2006 FDA's Proposed Ban of Over-The-Counter Skin Bleaching Products Detail-Document#: 221010 (subscription needed) http://www.prescribersletter.com