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obesity-related cancer

Etiology: a) large increases - uterine cancer - gallbladder cancer - hepatocellular carcinoma - renal cell carcinoma b) smaller increases in - hematologic malignancies - leukemia - non-Hodgkin's lymphoma - multiple myeloma - colorectal carcinoma - obesity in adolescent males increases risk for colorectal cancer later in life [6] - cervical cancer - ovarian cancer - post-menopausal breast cancer - pancreatic cancer - thyroid carcinoma c) stomach cancer & esophageal cancer in never smokers d) lower risk of - prostate cancer - pre-menopausal breast cancer [5] e) increased risk of meningioma (RR=1.5) [7] Laboratory: - increased serum IL-6 in patients newly diagnosed with type 2 diabetes is associated with an increased risk of obesity-related cancer [1]

General

malignant neoplasm (cancer)

References

  1. Bhattacharya S A Simple Blood Test May Predict Cancer Risk in T2D. Medscape. September 11, 2024 https://www.medscape.com/viewarticle/simple-blood-test-may-predict-cancer-risk-t2d-2024a1000gh4
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, 15, 16, 17, 18, 19. American College of Physicians, Philadelphia 1998, 2009, 2012, 2015, 2018, 2022. - Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
  3. Reeves GK et al, Cancer incidence and mortality in relation to body mass index in the Million Women Study: Cohort Study. BMJ 2007, 335:1134 PMID: 17986716
  4. Renehan AG et al, Body mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies. Lancet 2008, 371:569 PMID: 18280327 - Larsson SC and Wolk A Excess body fatness: An important cause of most cancers. Lancet 2008, 371:536 PMID: 18280312
  5. Bhaskaran K et al Body-mass index and risk of 22 specific cancers: a population- based cohort study of 5 24 million UK adults. The Lancet, Early Online Publication, 14 August 2014 PMID: 25129328 http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2960892-8/abstract
  6. Kantor ED et al Adolescent body mass index and erythrocyte sedimentation rate in relation to colorectal cancer risk. Gut. May 18, 2015 PMID: 25986947 http://gut.bmj.com/content/early/2015/04/28/gutjnl-2014-309007.abstract
  7. Niedermaier T et al Body mass index, physical activity, and risk of adult meningioma and glioma. Neurology. September 16, 2015 PMID: 26377253 http://www.neurology.org/content/early/2015/09/16/WNL.0000000000002020