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N-myc proto-oncogene protein (MYCN, NMYC)
Function:
- may function as a transcription factor
- efficient DNA binding requires dimerization with another bHLH protein
- binds DNA as an heterodimer with MAX
- interacts with JARID1A & JARID1B
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
Expression: expressed during fetal development
Pathology:
- defects in MYCN are the cause of Feingold syndrome
- defects in MYCN are the cause of microcephaly & digital abnormalities with normal intelligence
- amplification seen in neuroblastomas & other malignancies; amplification appears to increase as a tumor progresses
Related
N-myc proto-oncogene
General
myc protein family
phosphoprotein
proto oncogene protein
Properties
SIZE: entity length = 464 aa
MW = 50 kD
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T58}
Ser phosphorylation site {S62}
Ser phosphorylation site {S261}
acidic region {262-278}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S263}
DNA-binding motif
SITE: 381-394
helix-loop-helix
NAME: helix-loop-helix
SITE: 395-434
FOR-BINDING-VIA: helix-loop-helix
leucine zipper
SITE: 433-454
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM correlations
MORBIDMAP 164840
UniProt P04198
PFAM correlations
Entrez Gene 4613
Kegg hsa:4613
References
- Dwarki VJ, Montminy M, Verma IM.
Both the basic region and the 'leucine zipper' domain of
the cyclic AMP response element binding (CREB) protein are
essential for transcriptional activation.
EMBO J. 1990 Jan;9(1):225-32.
PMID: 2136830
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/NMYC112.html
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MYCN
- UniProt :accession P04198