N-acetyltransferase ESCO1; CTF7 homolog 1; establishment factor-like protein 1; EFO1p; hEFO1; establishment of cohesion 1 homolog 1; ECO1 homolog 1; ESO1 homolog 1 (ESCO1, EFO1, KIAA1911)

Function: 1) acetyltransferase 2) sister chromatid cohesion 3) coupling of cohesion & DNA replication - sister chromatid pairing 4) may function during S phase 5) phosphorylated during mitosis 6) phosphorylated upon DNA damage, probably by ATM or ATR Structure: - N-terminal region associates with chromosomes, thus the Zn finger is not needed for DNA association - belongs to the acetyltransferase family, GCN5 subfamily Compartment: - nucleus, nuclear at interphase - associated with chromosomes during mitosis Alternative splicing: named isoforms=3 Expression: - widely expressed - expressed in heart, brain, liver, placenta, lung, kidney, pancreas, muscle - highly expressed in muscle Note: - uncertain whether Met-1 or Met-2 is the initiator

General

acetyltransferase nuclear protein phosphoprotein zinc finger protein

Properties

SIZE: entity length = 840 aa MW = 95 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S31} Ser phosphorylation site {S200} Zinc finger NAME: Zinc finger SITE: 617-641 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 609674 UniProt Q5FWF5 Entrez Gene 114799 Kegg hsa:114799

References

UniProt :accession Q5FWF5