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N-acetylprocainamide (NAPA, Acecainide)
N-acetylprocainamide (NAPA) is a class III antiarrhythmic agent & the major metabolite of procainamide (a class Ia antiarrhythmic).
Laboratory:
1) specimen
a) serum, plasma (heparin, EDTA, oxalate)
b) stable for 6 months at -20 degrees C
c) collect for trough concentration
2) methods: HPLC, GLC, EIA, FPIA, FIA
3) analyze in conjunction with procainamide
4) interferences:
a) FPIA: heparin
b) hemolysis & lipemia interfere with all methods, but GC & HPLC
Therapeutic range: 6-30 ug/mL
Interactions
drug interactions
drug adverse effects (more general classes)
Related
N-acetylprocainamide in serum/plasma
General
acetate
antiarrhythmic agent, Group III
procainamide; novacainamide (Procan Pronestyl-SR)
Properties
MISC-INFO: 1/2life 6-8 HOURS
therapeutic-range 5-30 UG/ML
toxic-range >40 UG/ML
protein-binding 10%
elimination by hemodialysis +
Database Correlations
PUBCHEM correlations
References
- Manual of Medical Therapeutics, 28th ed, Ewald &
McKenzie (eds), Little, Brown & Co, Boston, 1995
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995