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N-acetylneuraminate lyase (NALase, N-acetylneuraminic acid aldolase, N-acetylneuraminate pyruvate-lyase, sialic acid lyase, sialate lyase, sialate-pyruvate lyase, sialic acid aldolase, NPL)
Function:
- catalyzes cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate & N-acetylmannosamine via a Schiff base intermediate
- prevents sialic acids from being recycled & returning to cell surface
N-acetylneuraminate N-acetyl-D-mannosamine + pyruvate
Structure: belongs to the DHDPS family, NanA subfamily
Compartment: cytoplasm
Alternative splicing: named isoforms=5
Expression:
- isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine, peripheral blood leukocyte
General
enzyme
Properties
SIZE: MW = 35 kD
entity length = 320 aa
COMPARTMENT: cytoplasm
MOTIF: Substrate binding {51-52}
proteolytic site {143-143}
lysine residue {K173}
Database Correlations
UniProt Q9BXD5
Pfam PF00701
ENZYME 4.1.3.3
References
UniProt :accession Q9BXD5