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beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III; N-acetylglucosaminyltransferase III; GlcNAc-T III; GNT-III (MGAT3, GGNT3)
Function:
- role in regulation of biosynthesis & biological function of glycoprotein oligosaccharides
- catalyzes addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains
- protein modification; protein glycosylation
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R
UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R
Structure: belongs to the glycosyltransferase 17 family
Compartment: Golgi membrane
General
glycoprotein
glycosyltransferase
membrane protein
phosphoprotein
Properties
SIZE: entity length = 533 aa
MW = 61 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {8-23}
proline-rich region
SITE: 35-86
MOTIF: proline residue (SEVERAL)
N-glycosylation site {N141}
N-glycosylation site {N241}
N-glycosylation site {N259}
Thr phosphorylation site {T261}
N-glycosylation site {N397}
Database Correlations
OMIM 604621
UniProt Q09327
Pfam PF04724
Entrez Gene 4248
Kegg hsa:4248
ENZYME 2.4.1.144
References
- UniProt :accession Q09327
- GGDB; Note: Glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/homolog?cat=symbol&symbol=MGAT3
- Functional Glycomics gateway - GTase
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyl-
transferase
http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_540