N-acetyl-D-glucosamine kinase; N-acetylglucosamine kinase; GlcNAc kinase (NAGK)

Function: - converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate - also has manNAc kinase activity (putative) ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate Structure: - belongs to the eukaryotic-type N-acetylglucosamine kinase family Expression: ubiquitous

General

kinase or ATP-phosphotransferase phosphoprotein

Properties

SIZE: entity length = 344 aa MW = 37 kD MOTIF: ATP-binding site NAME: ATP-binding site SITE: 6-13 binding site SITE: 36-36 FOR-BINDING-OF: Substrate Ser phosphorylation site {S76} binding site SITE: 107-107 FOR-BINDING-OF: Substrate Substrate binding {129-130} Substrate binding {145-147} binding site SITE: 152-152 FOR-BINDING-OF: Substrate Tyr phosphorylation site {Y205} ATP-binding site NAME: ATP-binding site SITE: 271-271 ATP-binding site NAME: ATP-binding site SITE: 275-275

Database Correlations

OMIM 606828 UniProt Q9UJ70 Pfam PF01869 Entrez Gene 55577 Kegg hsa:55577 ENZYME 2.7.1.59

References

UniProt :accession Q9UJ70