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N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2, NAALADL2)
Function: may be catalytically inactive
Structure:
- belongs to the peptidase M28 family, M28B subfamily
- although related to the peptidase M28 family, it is probably inactive as an hydrolase due to lack of the conserved Zn+2-binding & active sites
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- expressed at high level in kidney & placenta
- in embryo, it is mainly confined to duodenal & stomach endoderm, mesonephros, metanephros & pancreas
Genetics:
- gene maps to 3q26.31, a region associated with Cornelia de Lange syndrome
- specific mutations in a panel of DNA samples from patients with Cornelia de Lange syndrome not identified [2]
General
glycoprotein
membrane protein
Properties
SIZE: entity length = 795 aa
MW = 89 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {122-142}
N-glycosylation site {N295}
N-glycosylation site {N373}
N-glycosylation site {N534}
N-glycosylation site {N759}
Database Correlations
OMIM 608806
UniProt Q58DX5
References
- UniProt :accession Q58DX5
- Need authors, title...
PMID: 15168106