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N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L; ileal dipeptidylpeptidase; 100 kD ileum brush border membrane protein; I100 (NAALADL1, NAALADASEL, NAALADL)
Function:
1) NAALADase-like activity unknown
2) no NAAG hydrolyzing activity
3) dipeptidyl-peptidase IV type activity
4) cleaves Gly-Pro-AMC in vitro
5) release of an unsubstituted, C-terminal glutamyl residue, generally from Ac-Asp-Glu or folylpoly-gamma glutamates
Cofactor:
- binds 2 Zn+2 per subunit
Structure: belongs to the peptidase M28 family, M28B subfamily
Compartment:
- cell membrane, apical cell membrane
- ileal brush border membrane
Alternative splicing: named isoforms=8
Expression:
- expressed in the distal small intestine
- also expressed in the spleen & testis
- weak expression in the brain, mainly brain stem, amygdala, thalamus, ventral striatum
General
dipeptidase
glycoprotein
metalloprotein
Properties
SIZE: MW = 81 kD
entity length = 740 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {7-28}
N-glycosylation site {N136}
NAALADase. {263-579}
MOTIF: N-glycosylation site {N274}
N-glycosylation site {N299}
N-glycosylation site {N334}
N-glycosylation site {N345}
Zn+2-binding site
SITE: 368-368
Zn+2-binding site
SITE: 378-378
glutamate residue {E416}
Zn+2-binding site
SITE: 417-417
Zn+2-binding site
SITE: 445-445
N-glycosylation site {N451}
N-glycosylation site {N492}
Zn+2-binding site
SITE: 545-545
serine residue {S617}
aspartate residue {D657}
histidine residue {H680}
Database Correlations
OMIM 602640
UniProt Q9UQQ1
PFAM correlations
Entrez Gene 10004
Kegg hsa:10004
ENZYME 3.4.17.21
References
UniProt :accession Q9UQQ1